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Another pharmacology article on Vitamin D that does not mention the *need* to supplement with Vitamin K in tandem. Vitamin D will shake up the excess calcium in your system. My understanding is that if you have sufficient Vitamin K in your system as well, the calcium will be deposited in your teeth and bones. If you do not have sufficient Vitamin K, the calcium may be deposited in your organs and arteries. A few people I know got on the high dose Vitamin D3 bandwagon, which is good, but did not take Vitamin K2 with it -- because doctor didn't say it was necessary and what does a dope like me know anyway. One ended up with angina. One ended up with calcified valves in her heart -- and rather than adding K2 to try and move it, the doctor gave her pig valves. She's no longer with us. My opinion is that D3 is amazing, but always take it with a little K2 unless you are a heavy blood-thinner user.

Magnesium Glycinate will also work against the calcium deposition problems of high dose vitamin D3. One of the worlds leading D3 doctors is giving some patients such high dose D3 (40,000 IU daily that he has then take calcium glycinate. This doc (Dr. Coimbra) says that for such high D3 doses Mag Glycinate does what Vitamin K cannot.

https://www.coimbraprotocol.com/the-protocol-1
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perplexity AI>>>

Dr. Cicero Coimbra, known for his high-dose vitamin D3 treatment protocol for autoimmune diseases (the Coimbra Protocol), indeed prescribes very high doses of vitamin D3—sometimes up to 40,000 IU daily or even higher, depending on the patient and condition. His clinical approach involves doses that can range from about 35,000 to 300,000 IU per day under strict medical supervision.

Regarding magnesium glycinate, Dr. Coimbra highlights magnesium as a key cofactor in vitamin D metabolism. Magnesium helps activate vitamin D by supporting enzymatic conversions essential for vitamin D’s biological activity, a role that vitamin K does not fulfill. While vitamin K2 is often recommended alongside vitamin D3 to help guide calcium to bones and prevent vascular calcification, magnesium glycinate specifically aids the biochemical function of vitamin D in the body.

So, Dr. Coimbra’s treatment emphasizes that magnesium — particularly in forms like magnesium glycinate, which is well-absorbed — complements high-dose vitamin D3 therapy by enhancing vitamin D metabolism and function, especially at levels where normal vitamin K benefits might not suffice alone.

In summary:

Dr. Coimbra uses very high doses of D3 (35,000 to 40,000 IU daily and beyond) in autoimmune therapy.

Magnesium glycinate plays a crucial role in activating and metabolizing vitamin D, a function that vitamin K cannot replace.

Vitamin K still supports calcium regulation and cardiovascular health but doesn’t substitute magnesium’s biochemical role.

Such high-dose regimens require careful monitoring of calcium levels and kidney function, low-calcium diets, and ample hydration.

The protocol stresses the necessity of medical supervision for safety and effectiveness.

This is supported by clinical studies and detailed protocols available from Dr. Coimbra’s research and clinical practice.

Related
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How quickly do calcium and kidney markers change after starting high D3 plus mag glycinate