Study finds vitamin B3 and green tea compound help aging brain cells clean up

Medical Xpress / University of California, Irvine / GeroScience ^ | Aug. 6, 2025 | R. A. Santana et al

[dennisw]

You got a heaping helping of her longevity genes.......Hopefully.

[TheThirdRuffian]

In-law, so no. But my wife looks to be 29 (really) and she’s 50. Apache.

I look and feel young and healthy, excepting where Saddam blew me up and that’s more an annoyance than a problem.

My dad is still kicking at 96, shouldn’t drive but does, but my mom is not doing great in her 80s. But she never controlled her blood pressure, never took her meds, didn’t exercise, and was nuts her whole life. But both her parents were very healthy until late 90s and 101.

[TangoLimaSierra]

Wow! Good on granny. And your wife.

Some folks have the genetics that make it hard for nature to kill them.

[daniel1212]

You would die in 30 seconds without NAD+ providing energy to the mitochondria. It is available in capsules and powdered form as either NR (Nicotinamide Riboside) or NMN (Nicotinamide Mononucleotide). I prefer NMN because it doesn’t require as many steps to convert to NAD+ as NR and is slightly cheaper.

While take a multi-vit+min (when I remember), and drink some green tea, as a 73 yr. old male, 5;4'', 120lbs, and presently rather active, thanks be to God, by His grace and mercy. However, besides stiff arthritic typo-fingers, my mind is becoming increasingly forgetful, and slow, thus I am interested in this Vitamin And Tea Combo.

I do not see much on amazon under $20 for NMN, but are there any more side effects with NMN vs. NR?

I do not to spend much on any supplements, but here are some the products i am interested in, but have not chosen any yet except Extra Strength Green Tea Extract 9,000mg, 300 Capsules - $13.99 :

21st Century Niacinamide 500 mg Prolonged Release Tablet 4.99

NAD+ Supplement, 11000mg Liposomal Nicotinamide Riboside with Resveratrol & Quercetin $9.99

NAD Supplement, Nicotinamide Riboside, NAD 910MG

Liposomal Nicotinamide Riboside, 900mg Resveratrol NAD+ Supplement NMN Supplement

Nicotinamide Riboside 900,Liposomal Resveratrol

[ConservativeMind]

From my subscription at ConsumerLab, this is what they picked:

NAD/NADH: Top Pick for NAD/NADH is Swanson Maximum Strength NADH (break them in half, they said)

NR: Nicotinamide Riboside: Life Extension NAD+ 300 mg

NMN: Alive by Science NMN SL (Powder) (Company changed its name to “Renew by Science”)

I have taken nicotinamide riboside and sent some to a relative who had a 4 cm tumor on the outside of his liver, shown from multiple X-rays. He took it for a month and a half and the day before the surgery, they X-rayed again and it was totally gone. They canceled the surgery and didn't understand how it happened. My relative did tell them he took the NR, but I don't know if he also gave them that study information.

I gave him that, from this study writeup I posted a while back:

https://medicalxpress.com/news/2014-11-team-derivative-vitamin-b3-liver.html

He took 450 mg of nicotinamide riboside a day with a little betaine anhydrous and another component I'd need to look up.

There is a theoretical concern it could make some cancers grow. There was a study I posted on this specifically happening with triple-negative breast cancer, but the doses were quite high.

What I now do is take Renew by Science Nicotinamide Riboside powder each day with either a glass of green tea (two tea bags) or an EGCG only capsule of 150 mg EGCG with this NR powder. However, I only take a tiny amount every day instead of the high potency capsules I took several years back. I just take a 1/64 teaspoon of that powder and put it in the water (or now green tea). 1/64 is comfortably around the Upper Tolerable Limit of standard B3, but since it's not normal B3, the limit is not considered to hold for NR, and the European Union has a much higher limit for just NR, as studies show it's normally fine.

For safety on all sides, just get a 1/64 teaspoon in a cheap plastic teaspoon set and do that daily. The powder absorbs moisture quickly, so dump a bit out into another airtight container and keep the original airtight, separately. The powder is around $80 not on a sale, but it will last well over a year.

Take some green tea or green tea extract with your B3 / NR / NMR source and expect it should help. Also, look at a very low dose lithium orotate (1 mg, which is 1,000 mcg) and get a couple egg yolks or some lecithin each week for choline, as well, per the studies I put up this week, and with the other nutrition you get, I believe you will help fight potential dementia issues.

[daniel1212]

Thanks. Confused still, but btwn this

And https://www.amazon.com/gp/product/B0F1K7KSZM/ref=ox_sc_act_title_1?smid=A2EOYUEJ5J1KB4&psc=1

which is closest to the prescription?

[ConservativeMind]

Those appear to be the same product.

I would say the brand and item look illegitimate, especially for the price.

There are a lot of fake new brands that sell placebos on Amazon. They are Chinese companies hoping to get some quick money.

[ConservativeMind]

Just drink a cup of green tea with your vitamin containing vitamin B3.

[Freee-dame]

Awesome!

[daniel1212]

Just drink a cup of green tea with your vitamin containing vitamin B3.

Thanks. I perk a 1/2 gal of green (Uncle Lee's Tea - Organic Green Tea 100 Bag(@ $4.00) and black tea of which I drink daily, but I wondered about the amount of EGCG as well as Nicotinamide Riboside) or NMN (Nicotinamide Mononucleotide).

My mental processing ability at 73 has been alarmingly decreasing (which, among other things, curtails writing much, besides a physical factor), and in physical energy relative to summer work activity. so I thought the EGCG and Nicotinamide report may be worth a try, though I spend little on supplements.

I ended up buying https://www.amazon.com/dp/B0DVMFPFJ1?ref=ppx_yo2ov_dt_b_fed_asin_title and of

[ConservativeMind]

A bag of most caffeinated green teas should provide at least 50 mg of EGCG.

Don't use tea in plastic fabric, which is not too common, anyway.

Nicotinamide riboside and other forms of B3 have rather higher dosages we can safely take, which normal B3 does not.

If you try the lithium orotate from the other study, the goal is to use very little—less than 500 micrograms (500 mcg = 0.5 mg). The capsules I saw on Amazon are quite a bit higher than that, but a capsule from Life Extension could be dosed in half by opening it.

The other study I posted that day showed GABA and choline in the brain were also helpful for dementia. Foods can help you make GABA, while choline comes from egg yolks and lecithin. Both GABA and choline are available in supplements, too.

It was a great day or two of immediately useful studies and I was glad to post them.

[ConservativeMind]

These were the three dementia / Alzheimer’s therapy studies:

GABA
https://freerepublic.com/focus/f-chat/4334281/posts

EGCG
https://freerepublic.com/focus/f-chat/4334277/posts

Lithium
https://freerepublic.com/focus/f-chat/4334274/posts

[daniel1212]

Thanks, from not just me but many others I am sure who appreciate your posts on research. Grace and peace thru Jesus the Lord.