In National Lampoons: Vegas Vacation, Randy Quaid takes Chevy Chase to a more bargain oriented casino where they played more unorthodox games, so the idea of Uno isn’t so far fetched. They were just off by about three decades.
I think the game (as is) is too slowly resolved for Vegas to make money at it.
The players would have to be very high rollers, or it might work as a slot machine game.