These kind of public threats are almost certainly going to backfire on those Senators who will be running for re-election at some point. Some of those she is supposedly targeting clearly won’t be running for reelection so it will have no effect on them.
This is the only lever of pressure that works on professional politicians. They have no values, not principals no ethics beyond staying in power. The only way you penetrate the narcissistic fog these professional politicians walk around in is by posing a credible threat to that power.
She not talking about running against them. She is talking about targeting their power base inside their state parties. No Senator can ignore that threat because there dozens of people back home inside the party that want their Senate seat.