I think this is good for DeSantis as it frees him up to toss his hat into the ring for Rubio's seat. And he'd likely win it in a walk.
I don't see DeSantis getting a spot in Trump's administration. I don't really think he's a good fit and I think both men understand this. Yet, he turned Florida solid red and delivered it to Trump by 13 points so there should be some path for him to continue his political career.
I think DeSantis wants to be a Senator. I think he knows he’ll have a tough time beating out Vance in 2028.