Reliability is a problem in full or semi-auto .22 Magnums. It would be OK in a revolver.
But the general concept has already been tried , with some success, with the 5.7 X 28 FNs Rimfire .22 Mag ammo might be a little less expensive, although by the time you make it ‘mil-spec’ with a quality projectile, I doubt the savings would be significant
Should be a period(.) between “FNs” and “Rimfire” in my post above; the 5.7X28 are rimless centerfire cartridges as many of you know already.
I understand the concern.
However, my Keltec PMR 22 magnum has been 100% reliable with its 30 round magazines when used with recommended ammo.
Even with some “off brand” ammo not on their recommended list.
Of course, it’s never used in combat conditions.