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New research challenges notion that post-meal insulin surge is a bad thing
Medical Xpress / Lunenfeld-Tanenbaum Research Institute / eClinicalMedicine ^ | Dec. 13, 2023 | Dr. Ravi Retnakaran et al

Posted on 12/18/2023 10:15:35 AM PST by ConservativeMind

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To: ConservativeMind

I’ve been doing some research. This research is form the NIH.
They suggest a spectrum for which in the worst case a gall bladder removal is necessary but in the best case gall bladder removal in optional. They worry about the over prescription of gall bladder removal because of its effect on metabolic health.

They say

Thus, cholecystectomy may be an additional potential risk factor for the metabolic syndrome, independently of the original pathogenesis of gallstones, and even in the absence of major metabolic abnormalities prior to surgery (a possibility in pigment stone patients).

In patients with cholesterol gallstones, often harvesting already several metabolic disorders, cholecystectomy should be considered after careful selection of patients based on available clinical and epidemiological evidence, since gallbladder removal would act, at a systemic level, as a predisposing factor to the metabolic syndrome. Thus, current recommendations are further reinforced, i.e., cholecystectomy should be restricted to the subgroup of patients with symptomatic gallstones with colicky pain or complications of cholelithiasis or to the small group of patients requiring prophylactic cholecystectomy [1,4,48,66]. A further subgroup of patients with symptomatic uncomplicated cholelithiasis and small, cholesterol-enriched gallstones in a functioning gallbladder might benefit from oral litholysis with UDCA [4]. However, if cholecystectomy is unavoidable, all preventive measures including lifestyles and medical therapies should be considered to minimize additional metabolic risks.Nevertheless, both cohort surveys and experimental studies are strongly needed on this topic because of the high prevalence of cholecystectomy worldwide.

In patients at high risk, studies must address the role of SNPs and changes in gene expression secondary to epigenetic mechanisms [76,141], in order to identify tailored preventive and therapeutic strategies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118133/


21 posted on 12/19/2023 9:13:51 AM PST by ckilmer (ui)
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To: ckilmer

Something to consider, if you go forward with the surgery:

https://www.ajronline.org/doi/full/10.2214/ajr.182.2.1820451


22 posted on 12/19/2023 9:14:08 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I talked to the surgeon yesterday. The surgeon said that because of some scarring they would likely not be able to the minimally invasive laproscopic gall bladder removal—which is the one they prefer. but rather they would do a hard lateral cut in the abdomin.

the surgeon seemed to indicate that if I modified my diet to reduce fats—I might be able to avoid surgery.

The first bile acid I bought was something called TUDCA.

I see that you have suggested a couple more

Is it appropriate to stack these bile acids one on top of the other?

One the day before my visit to the doctor, I started drinking a lot of water. That resulted in a cup bile fluid flowing out of me. That’s the first time that’s happened since the operation. The doctor said that that’s a good thing. Because it means the gall bladder is draining. But I wonder if this is a good thing if it goes on day after day?


23 posted on 12/21/2023 7:22:46 AM PST by ckilmer (ui)
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To: ckilmer

How do you know the dark fluid was bile?

On the TUDCA, you will know you took too much by a day or two of the runs. Stacking is probably helpful, as it would get you other bile acids, but you could easily tilt it to “too much,” but that becomes inherently self-limited (i.e. - “I’m not going to do that much again, if I can keep from it.’).

We all really need to do what we can to preserve what health we can muster, or muster back. I’m glad you didn’t get the gall bladder removed, but work diligently to reverse your health issues to keep the surgery at bay, but don’t hurt yourself trying to do that.


24 posted on 12/21/2023 10:12:01 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Because the surgeon looked at it. It was greenish. she said it was bile.


25 posted on 12/21/2023 11:04:28 AM PST by ckilmer (ui)
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To: ConservativeMind

We all really need to do what we can to preserve what health we can muster, or muster back. I’m glad you didn’t get the gall bladder removed, but work diligently to reverse your health issues to keep the surgery at bay, but don’t hurt yourself trying to do that.

////

My family does not have a history of gall bladder or any kind of serious intestinal problems. But I do have a history of over reacting and over compensating. Maybe I mentioned this before... two of the risk factors for gall stones are: Fast weightloss and colesteral lowering drugs. I was doing both. The problems with my gall bladder started within a month or two more cholesteral lowering drugs and rapid weight loss.

I still want to drop another 10 pounds but I’ve stopped all the cholesteral lowering drugs. As well, I’m not too sure that its wise to have your ldl below 50 as mine was BEFORE I tripled my cholesteral lowering drugs.

So Yes, as you conclude, I’m seeing this as just one more balancing act to do. With the object being to hold on to as much good health as I can for as long as I can.

(On the frontiers of science—they’re making some pretty science fictionany promises as to what will be avialable to extend life—5-10 years from now.) When I’m healthy I believe them.

The surgeon said they did not remove the two gall stones they found. So I’ll do what I can to stack stuff. Low balling all of them.

Thanks for the advice.


26 posted on 12/21/2023 11:26:03 AM PST by ckilmer (ui)
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To: ckilmer

I believe you only want to take the bile replacements with an occasion you have fat, but I could be off on that for your circumstance.

It’s meant to help break down fats, then the bile gets recaptured and reused, not exiting with our poo.


27 posted on 12/21/2023 11:38:44 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I was recently in the hospital. My A1C number is just barely in the pre-diabetes range (6) so my doc has me on the meds. I’ve lost almost 50 pounds and my cholesterol numbers are great.

In the hospital they said I have out of control cholesterol and am diabetic. I was able to pull up the numbers for the blood test THEY HAD JUST TAKEN and show them that my cholesterol numbers are great and my A1C was a 6 and my glucose was 95.

They argued that because I was on meds for cholesterol and diabetes I MUST be a diabetic with cholesterol problems. My doctor put me on the meds so I WOULDN’T have cholesterol problems or become a diabetic. It didn’t matter...they were going to test my blood sugar every 8 hours and put me on the low cholesterol/diabetic meal plan. It was literally dry fish or chicken, steamed veggies, and pasta with no sauce for dinner.

Dipsh!ts


28 posted on 12/21/2023 11:56:29 AM PST by Crusher138 ("Then conquer we must, for our cause it is just")
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To: ckilmer

One of the problems with reducing fats is that without fats, you won’t ever push out bile.

Bile gets released when your body senses fat that need to be broken down.


29 posted on 12/21/2023 9:19:47 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

so you have to figure out how much fat you need. I’m aiming for one or two teaspoons of olive oil per day and maybe a bit more of odds and ends others.

do you have have a number you aim for?


30 posted on 12/22/2023 7:03:57 AM PST by ckilmer (ui)
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To: ckilmer
I merely try to keep my saturated, trans, and Omega-6 fats low, encouraging monounsaturated and Omega-3 fats.

We eat lower carb, sometimes approaching 80-100 net grams (obviously blowing past that for special occasions). We definitely enjoy olive oil and add some to foods in place of butter or coconut oil, where it can work well.

Amazingly, olive oil works great on much more than I ever thought it would.

From WebMD:

“Swap in Olive Oil

This staple of the heart-healthy Mediterranean diet is also good for your gallbladder. It's a great source of unsaturated fat, which prompts your gallbladder to empty. One study found that men who ate the most unsaturated fat were 18% less likely to have gallbladder disease than those who got the least. When cooking, switch butter with olive oil. Other healthy fat picks include fatty fish like salmon, nuts, and avocados.”

https://www.webmd.com/digestive-disorders/ss/slideshow-how-healthy-gallbladder

We eat at least half an avocado a day, too.

31 posted on 12/22/2023 7:42:04 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Yeah, thanks that’s about what I see.

I’ve had to throw out my nuts. not because they are bad. but I have no ability to eat them in moderation. too much, I’ve found wreck havoc on my digestive system. Found that out last sunday. still not quite over it. stomach is now very flighty. coffee now doesn’t agree with me.


32 posted on 12/22/2023 12:43:13 PM PST by ckilmer (ui)
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