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Thanks for responding - I looked up side effects for the N-Acetyl L-Glutamine amino acid component, and skin rash was a listed side effect. It doesn’t seem like an allergic reaction as I was taking it for over two weeks.

I started back up on a half dose with no rash yet.

Interesting. I wasn't aware of glutamine/rash connection. Others who have had the rash, however, including myself, came down with it before glutamine was part of the protocol. Now, for other reasons, glutamine is on the way out.

In his endless quest for the truth, Dmitry has made another switch in the protocol, now adding iron in the form of ferric citrate specificially. He has concluded that niacin + iron eliminates the need for glutamine and folic acid. With iron the amount of glutamine normally circulating in the body is sufficient, and with iron the gut bacteria will naturally produce sufficient folic acid.

In my opinion, you might as well use up the GPR109A you have, supplementing it with ferric citrate (Swanson's is the best and remarkably cheap). When you've used it up you can switch to PureBulk niacin (less than $10/bottle) along with the iron.

Business-wise, Dmitry has shot himself in the foot, because he was getting modest royalties from the GPR109A product. He has a history of doing that, by continually modifying the protocol to get it right.

I believe that the niacin has been providing me benefits from the get-go, three years ago. Although I've bought and thrown away a lot of different supplements as I've followed his experiments, it's been worth it.