Is that taking the freeways or diagonal highways across...just kidding. The six is a great way to get around.
I prefer to travel from 2200 to sunrise. The air is more calm at lower enroute airways, and the ATC Centers are much more personable and not hurried. Never holds and they usually skip STARs and just vector you to intercept ILS.
One does not desire to fly a seaplane at night. Everything is about reading the water surface. Hard to do at night.