[ConservativeMind]

It appears it takes out too many necessary blood components, not allowing them to ever return to the body, like apheresis does.

[ConservativeMind]

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[Secret Agent Man]

Perhaps it could be more effective and safer in a lower dose. Or various different doses, depending on what acute issue they are using it for.

[Skywise]

This is just worthless “science” - it’s a meta study based upon the cross analysis of several other studies and drawing a n overall conclusion for which none of the studies were designed to make.

It’s not a matter if using it doesn’t affect overall morality in the ICU if that morality wasn’t caused by Sepsis to begin with. If most of the ICU patients died of, say, heart failure unrelated to sepsis than the studies findings are nonsensical.

If their point is that sepsis isn’t generally a factor in the morality of ~1000 ICU deaths so it shouldn’t be used - that is also a fallacy because sepsis can be a very real issue (and, in fact, they make that point - that it just shouldn’t be a general practice but should be used where it’s necessary and Sepsis is an issue, which also shows that the study was nonsensical - Thanks Captain Obvious)