[ConservativeMind]

Folks, a recently available supplement, Urolithin A, directly activates this pathway, and the author does not appear to know this.

It is available from Nestle’s Celltrient division and from Timeline Nutrition.

[ConservativeMind]

Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis

“We showed that UA increases mitophagy flux and activates PINK1‐Parkin mitophagy pathway in both cell types. It also provides evidence that mitophagy activation is associated with better mitochondrial respiration, a key feature to support cellular function.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381911/

Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation

“Furthermore, UA administration rescued PINK1/Parkin-dependent mitophagy and relieved mitochondrial defects in the heart of obese mice, which led to improving cardiac diastolic function…”

https://www.nature.com/articles/s41401-022-00919-1

Urolithin A Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing STING-NLRP3 Axis-Mediated Inflammatory Response via Restoration of Parkin-Dependent Mitophagy

“Notably, UroA exhibited a scavenging effect against reactive oxygen species (ROS) and restored fructose-impaired PINK1/Parkin-mediated mitophagy in nephropathic mice.”

https://www.frontiersin.org/articles/10.3389/fphar.2022.907209/full

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[tired&retired]

Journal of Functional Foods
Volume 45, June 2018, Pages 95-99

Bifidobacterium pseudocatenulatum INIA P815:

The first bacterium able to produce urolithins A and B from ellagic acid

https://www.sciencedirect.com/science/article/abs/pii/S1756464618301324#:~:text=Pages%2095%2D99-,Bifidobacterium%20pseudocatenulatum%20INIA%20P815%3A%20The%20first%20bacterium%20able%20to%20produce,and%20B%20from%20ellagic%20acid

[e_castillo]

Thank you.