Not entirely, but a man has a better chance at self defense in a physical confrontation. Even the weakest male is usually stronger than most women.
My wife carries a cute little .45 ACP Kimber with a Crimson Trace. She puts in range time.
If only somebody made a tool, easy to use, that people could use to defend themselves ...
If only the ownership and carrying of such tools weren't restricted in the places such tools are needed most ...