Study finds loss of Menin helps drive the aging process, and dietary supplement can reverse it in mice (D-Serine)

Medical Xpress / Public Library of Science / PLoS Biology ^ | March 16, 2023 | Lige Leng et al

[ConservativeMind]

I agree.

[KittyKares]

Thank you for discussing our option of GlyNAC.

[nagant]

I’ve learned to be extremely careful of glycerine intake. I’m allergic. I don’t know if it’s just me, or if it’s just my age. I attribute the allergy to G3PDH reduction failure. But serine supplementation seems to enter the picture.

https://www.beingpatient.com/serine-supplements-efficacy-brain-health/

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.....a new study led by scientists from the University of California, San Diego casts doubt on serine’s effects and warns individuals to be careful if using the supplement.....

.....In the serine supplementation study in particular, the researchers found that the amount of a certain enzyme called phosphoglycerate dehydrogenase (PHGDH) in the brain of aging individuals is actually associated with Alzheimer’s risk.

The enzyme PHGDH is responsible for making serine in the body, suggesting serine is linked to cognitive decline. The exact nature of that link remains unclear, but the research team not only found no evidence that giving your brain extra serine was helpful — they found that the serine naturally produced by the brain is not associated with improving brain health, and in fact, may even be part of what propels cell death and cognitive decline.....
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[ConservativeMind]

No one is talking about glycerin in this study.

It is “glycine.”

[ConservativeMind]

The root paper you reference on L- and D-serine is available, here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531314/

It appears a defect in an early enzyme is common in Alzheimer’s patients, but can also be in people that do not have Alzheimer’s. Adding any form of serine, to some seemingly unknown level of supplementation, can cause issues that encourage Alzheimer’s issues for people with this defect.

Interesting, and worth noting for all reading this.

Thank you.

[Pete from Shawnee Mission]

CM thank you for these posts! Already have glycine and the NAC!