In the end, I believe Berberine will turn out better
Been taking berberine for two or three years — nothing to write home about, but does lower my A1C modestly.
Tried glucophage earlier but couldn’t tolerate even small doses (250mg).
Not in the same category, but Low-Dose Naltrexone is definitely helping me to lose weight (about 5% in three months). The LDN is combined with bupropion for synergistic effect.