So... aim for the nose?
Apparently YES! The skull ridge will stop even a mid-caliber round, like a .380 or 9mm, the chest has too many thick muscles, so I am seeing in reading about such attacks, that the nose is a effective path to the brain, and a round that enters through the front of the snout reaches the brain, and, well, lights out....
Of course that's the theory. I can't imagine having the nerve or skill to be able to hit such a target under stressful conditions; but then again I'm not a person that puts myself in such situations.
Aim for the shoulder. If you break the shoulder they are going down.