[steve86]

“Ketamine (”Special K”) has been successfully used to treat major depression for years.”

Therapeutic effect overstated and largely due to enthusiasm on the part of clinician-advocates. Also, at a practical level, costs are high ($400 minimum) and too many follow-up treatments required and too frequently. A long-lasting therapeutic effect is the exception, not the rule.

[steve86]

https://www.uptodate.com/contents/ketamine-and-esketamine-for-treating-unipolar-depression-in-adults-administration-efficacy-and-adverse-effects/print

Short summary: these can work in the short term when conventional antidepressants don’t, or as an adjunct to conventional ADs. Duration of effect is a real question, as is the number of required follow-up treatments (as many as 45 total treatments reported). Longer term treatment suitability and effectiveness are unknowns. Development of tolerance and dependence are possibilities. Diversion of medical drug supplies for private use has been reported, and crossover to illicit sources of the drug is possible.

[Az Joe]

You get your expert....I’ll get mine.