I would be interested in critiques from anyone with an Immunology background.
It’s VERY interesting.
Of course, vaccination’s protection against severe disease is mediated through T cells, not through antibodies. I saw a preprint last night that claims there’s no cellular immune boost after 3 doses of an mRNA vaccine (that is, 4, 5, etc don’t ADD to protection against severe disease).
But the IgG4 story as a cause of repeated non-severe infections looks good as well.