Without a groundwell of support, you are correct. But we can see evidence throughout history where the calls wear down folks and they eventually resign. The challenge is whether there is enough sustained anger to succeed.
We do? Nixon only resigned because he lost the support of the Republican leadership at the time.
If you imagine that Biden and/or Harris would be "worn down" by a handful of naive, disgruntled "conservatives" calling for their resignation, well, I'd have wonder what you're smoking.
With all due respect, people need to wake the eff' up and understand -- and accept -- the world in which they're actually living nowadays. Sheesh.