Things have grown so desperate in Kyiv in the way of effective air defenses, that the Ukrainians are literally having to resort to shooting at drones with rifles.
“Russia’s kamikaze drones. Protests, France & Moldova. Libya propaganda recycled. U/1”
https://www.youtube.com/watch?v=6ryrNQibEGo
In many cases, that seems to work.
The Iranian things are fairly large and not hard to spot.
And they are slow, as slow as a WWI aircraft.
A light machinegun in an old WWI-WWII type role should do well, as point defense.
The problem is warning time.