Posted on 08/21/2022 2:31:49 PM PDT by ConservativeMind
“ In summary, the present article made important revelations: First, treadmill exercise significantly mitigates both localized α-syn aggregation and spreading to different brain regions, resulting in prevention of neuronal demise. Second, treadmill exercise induces the activation of PPARα in neurons. Third, treadmill exercise up-regulates the autophagy-lysosomal pathway via PPARα-dependent transcription of TFEB. Fourth, heterozygous reduction of the CLN2 gene aggravates α-syn spreading and causes DA loss, emphasizing the importance of lysosome in α-syn pathology and indicating that the decrease in function of a pivotal lysosomal protein, TPP1, may increase the risk of α-synucleinopathy. Fifth, activation of PPARα by a prototype PPARα activator fenofibrate is also sufficient to reduce α-syn spreading and protect DAergic neurons. Therefore, either treadmill exercise or drug-mediated PPARα activation may be beneficial for preventing α-synucleinopathy and related neurodegeneration.”
>> Regular treadmill exercise helped ... mice
Even at the slowest speed, that’s a tremendous amount of running for the little guy.
Even at the slowest speed, that’s a tremendous amount of running for the little guy.
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They can handle the treadmill, but the stair-master is asking too much!
My local Y has exercise classes for Parkinson’s patients. One of them involves boxing.
Exercise activity is what keeps the brain in shape.
Multiple areas needed to maintain coordination. Plus some increased O2.
IIRC, 1 minutes of jump rope helps to prepare for the stair-master.
“Treadmill exercise shown to improve Parkinson’s symptoms in mice (Fenofibrate also helped)”
i had no idea that they made treadmills that small ...
Growing up, I was an all star athlete who played all 3 major sports.
After grad school, I joined local fitness club and still continue that membership.
As a very seasoned citizen, I do a HIIT program on an elliptical - normally 15-20 minutes 5-6x a week.
I very HIGHLY recommend anyone engaging in exercise programs is to invest in a heart monitor chest strap...for maximum health benefit and your own personal safety.
I am sure it’s a mouse sized treadmill. It would kill a little guy on a gym sized machine. Lol.
Wonder if it would benefit Alzheimer’s patients.
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