Interestingly, imipramine is an anticholinergic and its use has been implicated in the development of dementia at a later age, as have first-generation antihistamines. I would advise caution until they at least do RCT human studies.
As the writeup describes in a part I did not bring in, it is already being used by a number of Alzheimer’s patients, which is partly how they identified its benefit.