I’ve been on colchicine for a few weeks for an off label purpose. My DO said it can help with MCAS.
It’s an interesting drug as it’s one of the oldest known to man with it’s use recorded by the Greeks.
It worked great for my gout that’s for sure. Almost a miracle drug IMO.
Its name is derived from ancient greek as something close to "death to dogs".
It is quite toxic and needs to be used carefully. It basically halts cell mitosis - it stops cell division and that has to be tough on a lot of tissues.