I made the mistake of taking Ibuprofen about 9 years ago when I had flu symptoms and I probably took nyquil as well. The combination of that and stress I was undergoing at the time spiked my blood pressure and put me in an emergency room one morning till it went down naturally on its own.
I will NEVER touch Ibuprofen again if I never have to.
I am a heart patient on blood pressure medicine for years. I was told years ago not to take ibuprofen or alleve with my meds.