"After injection, the lipid nanoparticles (LNP) in the vaccines carry the mRNA instructions to your cells causing them to express Spike protein (known as "transfection"). These transfected cells are all over your body and are not limited to the injection site." The cells capable of transfection are throughout the body.
This image shows the process they undergo when the lipid nanoparticals enclosing the mRNA instructions undergo endocrytosis (a process by which cells absorb external material by engulfing it with the cell membrane) in these host cells:
mRNA delivered in an mRNA vaccine enters cells by endocrytosis and, after release from the endosome, is translated into protein by ribosomes. This process of ribosome translation--called transfection--is only possible in three types of host cells. They will, after administration of an mRNA vaccine intramuscularly, intracutaneously, or subcutaneously, be used by these three types of host cells: (1) non-immune cells (such as muscle cells and epidermal cells) at the injection site, (2) immune cells found in the tissues at the injection site (such as dendritic cells and macrophages) and, (3) immune cells in peripheral lymphoid organs after the injected mRNA is transferred through the lymphatic system to adjacent lymph nodes or the spleen. Translated proteins can then activate the immune system primarily in two ways:
i) Proteins are degraded by the proteasome into peptides subsequently presented as antigens on the cell surface by major histocompatibility complex (MHC) class I molecules which bind to the T cell receptor (TCR) to activate CD8+ T cells to kill infected cells through the secretion of perforin and granzyme.
ii) Proteins secreted extracellularly are engulfed by antigen-presenting cells (APCs) and degraded into peptides subsequently presented on the cell surface by MHC class II molecules for recognition by CD4+ T cells, which can activate both the cellular immune responses by secreting cytokines and the humoral immune responses by co-activating B cells.
In addition, single-stranded RNA and double-stranded RNA delivered in mRNA vaccines bind to Toll-like receptor (TLR) in the endosome to activate the antiviral innate immune responses via the production of type-I interferon (IFN-I) which results in the induction of several IFN-1-stimulated genes involved in antiviral innate immunity, in a mechanism known as the self-adjuvant effect of a sequence-engineered mRNA.
At no time do the ribosome produced Spike proteins remain in their original form. Instead they are degraded into antigen peptides to be used to create T-cells, programmed to attack the COVID-19 viruses' Spike proteins on its cell surface. These T-cells act as a contraceptive to the COVID virus. I am amazed that scientists have been able to understand how these transfection capable cells work and can be made to work for mankind's benefit. Much of the names for the science are not yet in most dictionaries. Through this science, we are on the threshold for a cure to Cancer and other ailments (Google: Can mRNA Treat Diseases?).
jonrick46 said: "At no time do the ribosome produced Spike proteins remain in their original form. Instead they are degraded into antigen peptides to be used to create T-cells, programmed to attack the COVID-19 viruses' Spike proteins on its cell surface. These T-cells act as a contraceptive to the COVID virus. I am amazed that scientists have been able to understand how these transfection capable cells work and can be made to work for mankind's benefit. Much of the names for the science are not yet in most dictionaries. Through this science, we are on the threshold for a cure to Cancer and other ailments (Google: Can mRNA Treat Diseases?)."~~~~~~~~~~
ransomnote said: This is not correct. Various researchers have detected spike proteins where they don't belong. Also, even if mRNA really had been what was bioaccumulating all over the body, that means the spike proteins would be produced (transfected) in places damaging to the body. Nothing the pharmas, FAUCI or Google sources say about the 'vaccines' is accurate or trustworthy.
I thought the following article was enlightening - spike proteins and antigens moving throughout the body.
‘We Made a Big Mistake’ — COVID Vaccine Spike Protein Travels From Injection Site, Can Cause Organ Damage • Children's Health Defense (childrenshealthdefense.org)
"When the purified spike protein is injected into the blood of research animals, they experience damage to the cardiovascular system and the protein can cross the blood-brain barrier and cause damage to the brain, Bridle explained.
The biodistribution study obtained by Bridle shows the COVID spike protein gets into the blood where it circulates for several days post-vaccination and then accumulates in organs and tissues including the spleen, bone marrow, the liver, adrenal glands and in “quite high concentrations” in the ovaries.
“We have known for a long time that the spike protein is a pathogenic protein, Bridle said. “It is a toxin. It can cause damage in our body if it gets into circulation.”
A large number of studies have shown the most severe effects of SARS-CoV-2, the virus that causes COVID, such as blood clotting and bleeding, are due to the effects of the spike protein of the virus itself.
A recent study in Clinical and Infectious Diseases led by researchers at Brigham and Women’s Hospital and the Harvard Medical School measured longitudinal plasma samples collected from 13 recipients of the Moderna vaccine 1 and 29 days after the first dose and 1-28 days after the second dose.
Out of these individuals, 11 had detectable levels of SARS-CoV-2 protein in blood plasma as early as one day after the first vaccine dose, including three who had detectable levels of spike protein. A “subunit” protein called S1, part of the spike protein, was also detected.
Spike protein was detected an average of 15 days after the first injection, and one patient had spike protein detectable on day 29 — one day after a second vaccine dose — which disappeared two days later."