“because it is broken down into adenine and methylthioadenosine—known toxic substances”
that’s odd ... because:
“most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase.”
who knew that the body makes and utilizes a toxic substance in more than 40 biochemical transformations ... no wonder everyone dies sooner or later ... could that be caused by these 40 toxic biotransformations?
https://en.wikipedia.org/wiki/S-Adenosyl_methionine
oh wait! “adenine is one of the four nucleobases in the nucleic acid of DNA that are represented by the letters G–C–A–T.” Who knew our DNA was toxic!
https://en.wikipedia.org/wiki/Adenine
“AND: 5′-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues.” It’s a wonder any of us are alive at all with all of these toxins that make up our being!
https://www.sciencedirect.com/science/article/abs/pii/S1357272503004199
I’ve used SAMe for years. Helps me sleep, takes the edge off any nervousness. I’m 82.
The scientists say we do need it and that we produce it, but the problem is that our bodies may not have processes to handle more than we might normally produce.
The reversal of the expected function of SAMe is a concerning development.