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To: Dead Dog

Clinically omicron looks different then delta. One is a URI one is an LRI. Much different clinical look. Radiology is different as well. Of the cases I saw positive this past week, two were sick and looks like delta and about 50 were mild or asymptomatic and tested for other reasons. Then I did the simple math.

But seriously they are much different clinical presentations.


10 posted on 01/21/2022 7:54:26 PM PST by gas_dr (Conditions of Socratic debate: Intelligence, Candor, and Good Will. )
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To: gas_dr; BeauBo
That brings up a considerable question, tho' I'm not sure if I know how to ask it correctly.

I do know some flu strains (typically the milder ones) tend to go for receptors in the Upper Respiratory Tract, and some of the typically nastier strains like H5N1 tend to go for receptors deep in the lungs. Is this what is happening with Omicron vs. Delta?

What has me puzzled is that Delta is described as generating exceedingly high viral loads in nasal passages: All seem to agree that's why it was much more infectious than earlier variants. Spreaders had mild head cold symptoms if any at all, and yet were able to chuck out astonishing virion quantities to those exposed to the spreader(s). I assumed this would happen B4 the infection progressed further in the spreader (lungs, bloodstream) making the occasional spreader / victim sick enough to go to the ER or be hospitalized. The "sick" with Delta ("sick" = your description - I'm not sure if that means seriously ill or hospitalized?) would only be a small fraction of those infected with Delta, unless they were hospitalized for something else. Only for purposes of discussion, I'll ballpark it at 10%. Nonetheless, if 10% of the Delta cases are "sick", that leaves 90% "mild or asymptomatic" by your description, some of whom one would expect to be in for other reasons, much as the Omicron cases. I am confused as to "where are they?"

The only explanations that make sense to me go back to previous discussions I had with BeauBo in which I concluded Delta is a sort of 2-stage disease: This from BeauBo's description of, in certain individuals, Delta moving on in from the upper respiratory tract to the lower respiratory tract and the bloodstream. OR, perhaps we have with Delta a situation where in approx. "10%" of the cases (contrived figure from above) Delta attacks the lower respiratory tract more directly(?), somewhat like H5N1, but in most cases attacks primarily the upper respiratory tract and would then be clinically indistinguishable from the even greater number of Omicron cases.

Personally, I think it's sequential, with some URI's progressing to LRI's, but, either way...

This would lead to me describing your cases in 2 groups: Group 1 = "Delta L" (the two LRI's.) Group 2 = Omicron + "Delta U" (the ~ 50 URI's). But, without sequencing or some other variant detecting test, Omicron vs. Delta U would be VERY difficult to differentiate. No?

OTOH, I suppose another consideration is that Delta L takes longer to develop, and the two "sick" cases you saw may therefor be Delta stragglers. So, new Delta infections might well be down to near zero, with all the Delta U cases pretty much having already run their course?

20 posted on 01/22/2022 7:34:01 AM PST by Paul R. (You know your pullets are dumb if they don't recognize a half Whopper as food!)
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To: gas_dr
Thanks to your dogged posts, I know the difference between Delta (lungs) and Omicron (throat/nose). Yesterday a colleague who(didn't know if she has Delta or Omicron) said the MAB caused the painful inflammation around the lungs or heart symptoms! An unvaccinated, midwesterner-Dec case. I can't wrap my head around the Republican antipathy to vaccines. In 1980, the Party divided itself forever over abortion (pro-abortion went Independent in my state) and now a deadly virus.

The Republican Party may not be able to vote Trump back in due to divisiveness,e.g., unhinged rage of your thread followers on FR.

25 posted on 01/22/2022 9:35:01 AM PST by The Westerner (Protect the most vulnerable: get the gov out of medicine, education and forests!)
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