[linMcHlp]

The PDF file is over 40 pages. The document's references are approx. 11 pages. This PDF file is stored at the Nevada Division of Public and Behavioral Health (DPBH).

An excerpt from the document [I have separated the paragraph, into portions, for easier reading]:

1. Biodistribution of mRNA Vaccines

Several studies on mRNA-based vaccines have confirmed independently that the spleen is a major center of activity for the immune response.

[NOTE: The next sentence is about a study of an mRNA-based influenza virus vaccine:]

A study on an mRNA-based influenza virus vaccine is extremely relevant for answering the question of the biodistribution of the mRNA in the vaccine.

This vaccine, like the SARS-CoV-2 vaccines, was designed as lipid nanoparticles with modified RNA coding for hemagglutinin (the equivalent surface fusion protein to the spike protein in corona viruses), and was administered through muscular injection.

The concentration of mRNA was tracked over time in various tissue samples, and the maximum concentration observed at each site was recorded. Not surprisingly, the concentration was highest in the muscle at the injection site (5,680 ng/mL). This level decreased slowly over time, reaching half the original value at 18.8 hours following injection.

The next highest level was observed in the proximal lymph node, peaking at 2,120 ng/mL and not dropping to half this value until 25.4 hours later. Among organs, the highest levels by far were found in the spleen (86.69 ng/mL) and liver (47.2 ng/mL). Elsewhere in the body the concentration was at 100- to 1,000-fold lower levels.

In particular, distal lymph nodes only had a peak concentration of 8 ng/mL. They concluded that the mRNA distributes from the injection site to the liver and spleen via the lymphatic system, ultimately reaching the general circulation.

This likely happens through its transport inside macrophages and other immune cells that take it up at the muscular injection site. Disturbingly, it also reaches into the brain, although at much lower levels (Bahl et al., 2017).

The European Medicines Agency assessment report for the Moderna vaccine also noted that mRNA could be detected in the brain following intramuscular administration at about 2% of the level found in the plasma (European Medicines Agency, 2021).

[Jonty30]

I think we are going to see an epidemic of heart attacks over the next 20 years, well beyond statistically would happen normally.

[BenLurkin]

Isn’t it a good thing if disease fighting mRNA could ultimately be incorporated into germ cell DNA for transgenerational transmission?

[precisionshootist]

Take a look at this video. It's only about 10 minutes. I agree with this doctor 100%. He uses logic and critical thinking coupled with objective observation to determine the TRUTH of what is going on with these "vaccines".

Well worth your time if you are interested in the truth and perhaps more importantly seeing an example of what it sounds like when someone is seeking the truth and speaking in good faith. There is so little of the latter going on today that I think most people can't even begin to know when they are hearing truth.

https://www.bitchute.com/video/LukPaRDJHysl/

[RushIsMyTeddyBear]

Bkmrk

[linMcHlp]

Antigen Presentation of mRNA-Based and Virus-Vectored SARS-CoV-2 Vaccines

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402319/

[linMcHlp]

How mRNA COVID-19 Vaccines Work to Fight COVID-19
https://www.youtube.com/watch?v=EEo9z99FbMU

[linMcHlp]

Vaccines and the Immune Response: How Vaccines Work
https://www.youtube.com/watch?v=Atrx1P2EkiQ

That video is produced by Mechanisms in Medicine
https://www.mechanismsinmedicine.com/site/home

Their YouTube channel
https://www.youtube.com/user/MechanismsMedicine/videos

[linMcHlp]

Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3

[EXCERPTS]

Highlights:

• mRNA vaccines generate antigen-specific T cells in a coordinated immune response

• Vaccine-induced T cells resemble the durable memory cells primed by infection

• Th1 and cTfh cell responses to the first dose correlate with second-dose responses

• SARS-CoV-2-recovered individuals benefit from the first but not the second dose

SUMMARY [Paragraph in portions, for easier reading]

SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming.

We performed longitudinal antigen-specific T cell analyses on healthy SARS-CoV-2-naive and recovered individuals prior to and following mRNA prime and boost vaccination.

Vaccination induced rapid antigen-specific CD4+ T cell responses in naive subjects after the first dose, whereas CD8+ T cell responses developed gradually and were variable in magnitude.

Vaccine-induced Th1 and Tfh cell responses following the first dose correlated with post-boost CD8+ T cells and neutralizing antibodies, respectively.

Integrated analysis revealed coordinated immune responses with distinct trajectories in SARS-CoV-2-naive and recovered individuals.

Last, whereas booster vaccination improved T cell responses in SARS-CoV-2-naive subjects, the second dose had little effect in SARS-CoV-2-recovered individuals.

These findings highlight the role of rapidly primed CD4+ T cells in coordinating responses to the second vaccine dose in SARS-CoV-2-naive individuals.

DISCUSSION [EXCERPT paragraph in portions, for easier reading]

One key observation was the rapid and universal induction of SARS-CoV-2-specific CD4+ T cells following the first vaccine dose in SARS-CoV-2-naive individuals.

This observation may be noteworthy given the gradual development of antigen-specific CD8+ T cells observed here and the previous observations for humoral responses (Goel et al., 2021; Jackson et al., 2020), which only consistently reach maximal levels after the second vaccine dose.

These data point to the early induction of antigen-specific CD4+ T cells as a possible contributor to the protection observed in clinical trials as early as two weeks after the first vaccine dose (Baden et al., 2021; Polack et al., 2020), when neutralizing antibody titers are still low in many individuals (Goel et al., 2021).

Indeed, CD4+ T cells can prevent symptomatic SARS-CoV infection in animal models (Zhao et al., 2016), and the rapid induction of antigen-specific CD4+ T cells after only a single vaccine dose may explain the disconnect between low neutralizing responses and vaccine-induced protective immunity following the first dose.

[linMcHlp]

All Types of COVID-19 Vaccines, How They Work, Animation.
https://www.youtube.com/watch?v=osRo-yz1VQ8

That is a pretty good video; 5:55 min. This video provides extra tidbits of info, not normally found in other such, relatively short, videos.

[metmom]

Covid ping

[Varsity Flight]

📌

[Tilted Irish Kilt]

Infectious Disease ping - Covid vaccines explained authoritatively for scientific, as well as lay personel who desire general information.

(My comment) This is a comprehensive,succinct and scientific medical research discussion, with resources, corporal responses and reactions, pathologies,
transmissions, and possible unintended consequences of mRNA vaccines.
This posted discussion includes references,footnotes for the scientific reader,
as well as ongoing comments which include youtube and prior FR comments and postings for easier lay personnel understanding.

(From the OP): "The PDF file is over 40 pages. The document's references are approx. 11 pages.
This PDF file is stored at the Nevada Division of Public and Behavioral Health (DPBH)."

(Continues from the OP): " We then review both components of, and the intended biological response to, these vaccines, including production of the spike protein itself,
and their potential relationship to a wide range of both acute and long-term induced pathologies,
such as blood disorders, neurodegenerative diseases and autoimmune diseases."

"Among these potential induced pathologies, we discuss the relevance of prion-protein-related amino acid sequences within the spike protein."

"We also present a brief review of studies supporting the potential for spike protein “shedding”,
transmission of the protein from a vaccinated to an unvaccinated person, resulting in symptoms induced in the latter."

"We finish by addressing a common point of debate, namely, whether or not these vaccines could modify the DNA of those receiving the vaccination."

H/T to linMcHlp for providing this information !