Replies

Yeah I don’t have time to read each one of those and I don’t have that much interest in continually pointing out your Links and not saying anything different than me.

This link for example: https://journals.lww.com/americantherapeutics/Fulltext/2021/08000/Ivermectin_for_Prevention_and_Treatment_of.7.aspx

“ Data sources:

We searched bibliographic databases up to April 25, 2021. Two review authors sifted for studies, extracted data, and assessed risk of bias. Meta-analyses were conducted and certainty of the evidence was assessed using the GRADE approach and additionally in trial sequential analyses for mortality. Twenty-four randomized controlled trials involving 3406 participants met review inclusion.

Therapeutic Advances:

Meta-analysis of 15 trials found that ivermectin reduced risk of death compared with no ivermectin (average risk ratio 0.38, 95% confidence interval 0.19–0.73; n = 2438; I2 = 49%; moderate-certainty evidence). This result was confirmed in a trial sequential analysis using the same DerSimonian–Laird method that underpinned the unadjusted analysis. This was also robust against a trial sequential analysis using the Biggerstaff–Tweedie method. Low-certainty evidence found that ivermectin prophylaxis reduced COVID-19 infection by an average 86% (95% confidence interval 79%–91%). Secondary outcomes provided less certain evidence. Low-certainty evidence suggested that there may be no benefit with ivermectin for “need for mechanical ventilation,” whereas effect estimates for “improvement” and “deterioration” clearly favored ivermectin use. Severe adverse events were rare among treatment trials and evidence of no difference was assessed as low certainty. Evidence on other secondary outcomes was very low certainty.”

((((Ok, so they used 3,406 participants from numerous and various Countries. Good. They’re 95% confidant the methods and research was done correctly. Good. Reduced infection was an average of 86%. Good.

“ Low-certainty evidence suggested that there may be no benefit with ivermectin for “need for mechanical ventilation…..”
So again, in Severe Cases Ivermectin does Not increase positive outcomes.))))

Again from the link:

COVID-19 treatment studies
Ahmed 202023 Bangladesh Double-blind BPL(Pharma); Bangladesh, Canada, Sweden, and UK govt Mild to moderate COVID (inpatients) 72 12 mg × 1 day or × 5 days (3 study arms)* Placebo Published in PR journal; emailed/responded with data Time to viral clearance (PCR –ve), remission of fever and cough within 7 days, duration of hospitalization, mortality, failing to maintain sats >93%, adverse events, PCR –ve at 7 and 14 days
Babalola 2020105 Nigeria Double-blind Self-funded Asymptomatic, mild or moderate COVID (45 inpatients and 17 outpatients) 62 6 mg every 84 hrs × 2 wks (arm 1) or 12 mg every 84 hrs × 2 wks (arm 2) Ritonavir/lopinavir MedRxiv preprint: emailed/responded with data. Paper accepted for publication Time to PCR –ve, laboratory parameters (platelets, lymphocytes, clotting time), clinical symptom parameters
Bukhari 2021135 Pakistan Open-label None reported Mild to moderate COVID (inpatients) 100 12 mg × 1 dose SOC MedRxiv preprint Viral clearance, any adverse side effects, mechanical ventilation
Chaccour 202024 Spain Double-blind Idapharma, ISGlobal, and the University of Navarra Mild COVID (outpatients) 24 0.4 mg/kg × 1 dose Placebo Published in PR journal PCR +ve at day 7, proportion symptomatic at day 4,7,14,21, progression, death, adverse events
Chachar 2020112 Pakistan Open-label Self-funded Mild COVID (outpatients) 50 12 mg at 0, 12, and 24 hours (3 doses) SOC Published in PR journal Symptomatic at day 7
Chowdhury 2020136 Bangladesh Quasi-RCT None reported Outpatients with a +ve PCR (approx. 78% symptomatic) 116 0.2 mg/kg x1 dose* HCQ 400 mg 1st day then 200 mg BID × 9 days + AZM 500 mg daily × 5 days Research square preprint Time to –ve PCR test; period to symptomatic recovery; adverse events
Elgazzar 202047 Egypt RCT None reported Mild to severe COVID (inpatients) 200 0.4 mg/kg daily × 4 days HCQ 400 mg BID × 1 day then 200 mg BID × 9 days Research square preprint: emailed/responded with data Improved, progressed, died. Also measured CRP, D-dimers, HB, lymphocyte, serum ferritin after one week of treatment
Fonseca 202144 Brazil Double-blind Institution-funded Moderate to severe (inpatients) 167 14 mg daily × 3 days (plus placebos × 2 additional days) HCQ—400 mg BID on day 0 then daily × 4 days; CQ -450 mg BID day 0 then daily × 4 days Prepublication data/manuscript in progress obtained via email Death, invasive mechanical ventilation
Gonzalez 2021137 Mexico Double-blind Institution-funded Moderate to severe (inpatients) 108 12 mg × 1 dose Placebo MedRxiv preprint Length of hospital stay, invasive mechanical ventilation, death, time to negative PCR
Hashim 2020138 Iran Quasi-RCT None reported Mild to critical (inpatients) 140 0.2 mg/kg × 2 days*
Some had a 3rd dose a week later SOC MedRxiv preprint Death, mean time to recovery, disease progression (deterioration)
Krolewiecki 2020106 Argentina Open-label None reported Mild to moderate (inpatients) 45 0.6 mg/kg/d × 5 days Placebo Research Gate and SSRN preprints Viral load reduction in respiratory secretions day 5, IVM concentrations in plasma, severe adverse events
Lopez-Medina 202185 Columbia Double-blind Institution-funded Mild (outpatients) 476 0.3 mg/kg elixir × 5 days Placebo Published in a PR journal Resolution of symptoms within 21 days, deterioration, clinical condition, hospitalization, adverse events
Mahmud 2020107 Bangladesh Double-blind None reported Mild to moderate COVID (inpatients) 363 12 mg × 1 dose* Placebo + SOC Data published on clinical trial registry and clarification obtained via email Improvement, deterioration, late clinical recovery, persistent PCR test +ve
Mohan 2021110 India Double-blind Institution-funded Mild to moderate 152 12 mg or 24 mg elixir × 1 dose Placebo MedRxiv preprint research Conversion of RT-PCR to negative result, decline of viral load at day 5 from enrollment
Niaee 2020108 Iran Double-blind Institution-funded Mild to severe COVID 180 0.2 mg/kg × 1 and 3 other dosing options) ∼ 14 mg tablet† Placebo Research Square preprint Deaths, length of stay, biochemical parameters
Okumus 2021115 Turkey Quasi-RCT None reported Severe COVID 66 0.2 mg/kg × 5 days SOC Prepublication data/manuscript in progress obtained via email Clinical improvement, deterioration, death, SOFA scores
Petkov 2021139 Bulgaria Double-blind Pharma-funded Mild to moderate COVID 100 0.4 mg/kg × 3 days Placebo Prepublication data obtained from another source Rate of conversion to PCR negative
Podder 2020140 Bangladesh Open-label

((((The cases being studied are almost exclusively Mild or Mild to Moderate. A couple of severe cases where used but not report or findings presented.

Once again, this is what I’ve been saying.))))

So I don’t know what you’re purpose is, what you’re out to prove or disprove.
But I have a life to live and Covid and vaccines isn’t a major part of it.

Have a great day. Glad you helped demonstrate that what I’ve been saying matches all of the most up to date data out there.

Thanks again.