My wife and I recently cut out our folic acid supplement and food sources in favor of a multivitamin with only active forms of B-vitamins, which eliminates conversion steps that may not be properly working.
The “methylation” described is an action some active forms of B vitamins can help achieve, but may more commonly be performed in the body by other processes via choline (egg yolks) betaine/trimethylglycine (beets), and other food-based sources.
Epigenomic DNA methylation is one of the reasons every cell in your body can have the same DNA in the nucleus and yet can differentiate into all the functionally specific cells to make muscle, blood, liver, brain, etc. This differentiation is communicated between cells as they exchange sacs of information molecules following a shared template that is yet to be fully understood.
The exact gene sites where methylation takes place are very complex and any drug that targets one site must be specifically tailored to only modulate the desired gene and not affect other cells in the body.
This is why I’m skeptical of any broad methylation therapy that could have significant side effects until we fully understand how to localize the delivery of the molecules to the right DNA location. This is where CRISPR guide molecules may be useful to only deliver the methylation at the site that matches a specific DNA site. This therapy needs a rifle, not a shotgun.
For my brother and I, when we take folic acid, it seems to make our emotions more intense.