Last winter 2021, I had asked
jonrick46, about, what you now wonder. The following notes are some of what
jonrick46 wrote, plus my own clarifications [I hope]:
Only a few cells have MHC-1 and MHC-2 complex molecules. [Those being cells that can present viral peptides within Major Histocompatibility Complex ("MHC" class I and class II) antigens. See trailing notes, re "MHC Class II molecules."]
The Messenger RNA [non-replicating "mRNA" type of "vaccine" when production control is precisely successful] is specifically designed to fuse and deliver its RNA blueprint into [those specific cell types mentioned, that are supposed to be, of the immune system].
Cells with the MHC-1 molecules are the B cells (lymphocites), macrophages (white blood cells) and dendritic cells.
Cells with the MHC-2 molecules are [also] cells with a nucleus.
Those cell with the MHC-1 and MHC-2 complexes, [have a specialized function that] only translates the RNA so it [is expressed as the Spike Protein] on the MHC-1 complex or the MHc-2 complex at the host cell surface, depending on what type of cell they are . . .
Once [T helper cells are] in contact with these foreign proteins, there is an interaction with the T helper cells which trigger them to produce cytokines (interleukins) and memory cells.
The interleukins attract B-cells that produce plasma cells which act to produce antibodies with a molecular memory that will bind on the C-virus's Spike protein, whenever present from that time on, neutralize it and destroy it.
But, jonrick46 also specifically wrote:
The cytoxic T-cells do not destroy the host cell making Spike Proteins. They destroy future host cells that are infected by the COVID-19 virus.
More info, re Translation, see:
https://en.wikipedia.org/wiki/Translation_(biology)
There: "MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses."
"In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or endoplasmic reticulum synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus. The entire process is called gene expression."
More info, re MHC class II, see:
https://en.wikipedia.org/wiki/MHC_class_II
There: "MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses."
For nitty gritty details, go to:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402319/
Scroll down to: "The mechanism of action of an mRNA vaccine is very similar to the mechanism of viral infection. By means of the translational machinery of the host cells, the mRNA is translated into proteins. These proteins may undergo post-translational modification and either function within the cell or be secreted."
Also at that last link, see:
2.2.4. Immune Response
The general idea, is to innoculate into deltoid muscle tissue, and thus, also be in the vicinity of your left or right axillary (lymph node complex), in order to use the facilities mentioned:
"In humans, FDG-PET scans of recently vaccinated patients showed increased uptake in the deltoid muscle, corresponding to the vaccine injection site as well as in the ipsilateral (enlarged) axillary lymph nodes [50]. While latter data do not allow for differentiating between different cell types, they do indicate that intramuscular injection leads to the metabolic activation of local tissue."
Some of the success of that, is promoted by whomever adminsters the "vaccine," taking the time to aspirate "the shot." IMHO. And, if for some reason - such as a war wound - you do not have an axillary on the left side, you might want to have "the shot" administered on your right. HINT.
Reply
32 by
jonrick46 at
New Research Shows Why the COVID19 “Vaccines” are Killing Professional Athletes
The mRNA lipid nanoparticles are
not Spike Protein.
(1) Injected mRNA vaccines are endocytosed by antigen-presenting cells.
(2) After escaping the endosome and entering the cytosol, mRNA is translated into protein by the ribosome. The translated antigenic protein can stimulate the immune system in several ways.
(3) Intracellular antigen is broken down into smaller fragments by the proteasome complex, and the fragments are displayed on the cell surface to cytotoxic T cells by major histocompatibility complex (MHC) class I proteins.
(4) Activated cytotoxic T cells kill infected cells by secreting cytolytic molecules, such as perforin and granzyme.
(5) Additionally, secreted antigens can be taken up by cells, degraded inside endosomes and presented on the cell surface to helper T cells by MHC class II proteins.
(6) Helper T cells facilitate the clearance of circulating pathogens by stimulating B cells to produce neutralizing antibodies, and by activating phagocytes, such as macrophages, through inflammatory cytokines. BCR, B cell receptor; ER, endoplasmic reticulum; TCR, T cell receptor.
Spike Proteins in this process are
never set loose into the circulatory system. Instead, they are broken up or presented on the cell surface to helper T cells by MHC class II proteins.