No the pathophysiology has nothing to due with your pejorative “clot shot”. Sidenafil is a ventilator and acts on the endothelial layer of the pulmonary vasculature causes decrease in diffusion space which in turn increases oxygen as in the case of ARDS.
Sidenafil has been long used in such a capacity, and the erectile dysfunction treatment is actually a by product of what it was originally intended for.
It's a ventilator? Wow! I learn something new here every day.
Correct. Believe as the brand name Revatio it has a patent extension and exclusivity for 80mg/day dosing for Right Sided Congestive Heart disease... pulmonary hypertension. The agent was in phase trials for this indication and approval, when, during the double blinded placebo controlled trials some placebos were clearly not placebos (the side effect of vascular erectile tissue being perfused, and voila- up goes Bob’s uncle john). The placebo group were discovered to having secreted their “dosing” (in the pill counts done with all groups) and the researchers questioned the study members, who revealed the desirable response. All true, and verified by clinicians supervising and enrolled in the trials.
When did you get certified as an immunologist?
Your job is rendering people unconscious without killing them so other doctors can perform surgery. Keeping up on that is a full time job. When do you find time to practice medicine outside your specialty?
L