Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US

jamanetwork.com/journals ^ | December 28, 2021 | Jing Sun, MD, MPH, PhD1; Qulu Zheng, MS1; Vithal Madhira, MS2; et al

[ransomnote]

[H/T Dalberg-Acton ]

Key Points

Question  Is immune dysfunction associated with an increased risk for COVID-19 breakthrough infection after SARS-CoV-2 vaccination?

Findings  In this cohort study of 664 722 patients who received at least 1 dose of a SARS-CoV-2 vaccine, those with immune dysfunction, such as HIV infection, rheumatoid arthritis, and solid organ transplant, had a higher rate for COVID-19 breakthrough infection and worse outcomes after full or partial vaccination, compared with persons without immune dysfunction.

Meaning  The findings suggest that persons with immune dysfunction are at much higher risk for contracting a breakthrough infection and thus should use nonpharmaceutical interventions (eg, mask wearing) and alternative vaccination approaches (eg, additional dose or immunogenicity testing) even after full vaccination.

ransomnote: abstract and full article available (includes download) at link 

 

Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US | HIV | JAMA Internal Medicine | JAMA Network

 

[Pelham]

Yeah I saw that piece earlier. Kirsch is a Silicon Valley money guy and like many of the clowns from SV imagines that wealth has magically granted him expertise in unrelated fields. There’s a few writers at Substack posting good work, he’s not one of them.

[CatHerd]

Well, he’s certainly popular here among a certain crowd.

Your explanation makes good sense. As usual.

Happy New Year to you and yours!