There is a simple test. Answer the question in your head as if it were asked in the singular. If the answer is me, then that’s it, but if the answer is I then that’s it. But be aware that me and you is a frequent case of bad grammar in 21st Century America.
You and I
Are subject to
The blues now and then...
It just doesn’t sound right. Nor would Bo Diddley singing, “Whom do you love?”