I take Jardiance for diabetes.
It has been very effective on my A1C with no side effects.
Expensive though.
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It’s got a long way to go. The FDA has found a lot of problems in their screenings to include:
FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes
FDA Drug Safety Communicaion: FDA confirms increased risk of leg and foot amputations with the diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR)
FDA Drug Safety Communication: FDA strengthens kidney warnings for diabetes medicines canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR)
FDA Drug Safety Communication: Interim clinical trial results find increased risk of leg and foot amputations, mostly affecting the toes, with the diabetes medicine canagliflozin (Invokana, Invokamet); FDA to investigate
FDA Drug Safety Communication: FDA revises labels of SGLT2 inhibitors for diabetes to include warnings about too much acid in the blood and serious urinary tract infections
FDA Drug Safety Communication: FDA revises label of diabetes drug canagliflozin (Invokana, Invokamet) to include updates on bone fracture risk and new information on decreased bone mineral density
Don’t look for it to be available right away. They have a lot of work to do and it is normal to be years into a study of a drug before it hits the shelves. The C-19 drugs are an example as they were slammed in too quickly as they are finding at the moment.
wy69
bkmk
JARDIANCE side effects:
Necrotizing fasciitis. A rare but serious bacterial infection that causes damage to the tissue under the skin in the area between and around your anus and genitals (perineum). This bacterial infection has happened in women and men who take JARDIANCE, and may lead to hospitalization, multiple surgeries, and death.
Seek medical attention immediately if you have fever or are feeling very weak, tired or uncomfortable (malaise), and you develop any of the following symptoms in the area between and around your anus and genitals: pain or tenderness, swelling, and redness of skin (erythema).
Vaginal yeast infection. Talk to your healthcare provider if you have vaginal odor, white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese), and/or vaginal itching.
Yeast infection of the penis. Swelling of an uncircumcised penis may develop that makes it difficult to pull back the skin around the tip of the penis. Talk to your healthcare provider if you have redness, itching or swelling of the penis, rash of the penis, foul smelling discharge from the penis, and/or pain in the skin around the penis.
Talk to your healthcare provider about what to do if you get symptoms of a yeast infection of the vagina or penis. Your healthcare provider may suggest you use an over-the-counter antifungal medicine. Talk to your healthcare provider right away if you use an over-the-counter antifungal medication and your symptoms do not go away.
Allergic (hypersensitivity) reactions. Symptoms of serious allergic reactions to JARDIANCE may include: swelling of your face, lips, throat and other areas of your skin, difficulty with swallowing or breathing, raised, red areas on your skin (hives). If you have any of these symptoms, stop taking JARDIANCE and contact your healthcare provider or go to the nearest emergency room right away.
thanks for the post. once again, I learned something from reading FR!
“A normal heart’s ejection fraction may be between 50 and 70 percent.
You can have a normal ejection fraction measurement and still have heart failure (called HFpEF or heart failure with preserved ejection fraction).
If the heart muscle has become so thick and stiff that the ventricle holds a smaller than usual volume of blood, it might still seem to pump out a normal percentage of the blood that enters it. In reality, though, the total amount of blood pumped isn’t enough to meet your body’s needs.
What’s too low?
A ejection fraction measurement under 40 percent may be evidence of heart failure or cardiomyopathy.
An EF from 41 to 49 percent may be considered “borderline.” It does not always indicate that a person is developing heart failure. Instead, it may indicate damage, perhaps from a previous heart attack.”
https://www.heart.org/en/health-topics/heart-failure/diagnosing-heart-failure/ejection-fraction-heart-failure-measurement#:~:text=A%20normal%20heart%E2%80%99s%20ejection%20fraction%20may%20be%20between,and%20stiff%20that%20the%20ventricle%20holds%20a%20smaller
Health concerns that increase the risk of heart disease also increase risk of heart failure. These include obesity, high cholesterol, diabetes, kidney disease, and tobacco use.
Diet and exercise work better than any drug.
I’ve taken Jardiance for a couple years now with no problems. It started helping me to lose weight right away. I now also take Ozempic which accelerated the weight loss - I’ve lost about 60 pounds from peak weight, and A1C has remained around 7. If this keeps up I’ll have to change my screen name.