[Pelham]

“Bottom line cheap and proven safe Ivermectin is significantly more effective in treating covid than the new, uber expensive, unproven, uncertified and, according to the paper, potentially dangerous Molnupiravir.”

The research paper doesn’t say that at all. It actually says this, easily found in the “abstract” box:

“M is a more potent antiviral drug and IV has a longer residence in the body. Their effects on RdRp and cytokine inhibition are potentially complimentary for anti-COVID-19 activity”

Freepers need to read the actual source themselves instead of believing phony summations like you have concocted.

https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf

[SoConPubbie]

Whatever the research paper says or doesn't say, I'll take the real-world evidence of the total effectiveness of the Indian states of New Delhi and Utter Pradesh over anything else.

These two states totally obliterated their daily case totals and deaths by proscribing and employing Ivermectin for COVID-19.

[rdcbn1]

I did read the paper - several times and in great detail. I also followed up reading several of the references in the paper. I assume you dis as well. On the first page —There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells [9]. This is a pretty darn significant concern IMHO.

[rdcbn1]

“M is a more potent antiviral drug and IV has a longer residence in the body. Their effects on RdRp and cytokine inhibition are potentially complimentary for anti-COVID-19 activity”
———————————— M is a more “potent” drug because it has much faster uptake into the bloodstream and it is works at lower concentrations than Ivermectin . M also has a much lower half life than Ivermectin which means you need more doses ove a course of treatment. The papers comments spoke to the comparative dosing characteristics for clinical effectiveness , not to the actual efficacy of the drug at fighting covid virus. In this, Ivermectin is more effective of the two

[LilFarmer]

“ Molnupiravir active metabolite (NHC-5’ Triphosphate), acts as a competitive alternative substrate for the viral RNA dependent RNA polymerase (RdRp), causing viral mutagenesis or transition mutations, which leads to viral error catastrophe and extinction of replication [8].

There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells [9]. Ivermectin (Table 1) exhibits multifarious actions, ranging from binding to SARS-CoV-2 spike protein S, reducing cell entry via human ACE2 receptors, inhibition of the nuclear transport of viral proteins, which prevents interference with replication, to binding to RdRP, reducing the activity of the viral transcription -replication complex [10]. Ivermectin has additional effects on Signal Transduction Activation of Transcription (STAT-3) and inhibition of cytokine production and inflammation, which has not yet been shown for molnupiravir.”

https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf