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Molnupavir is completely unlike Ivermectin. Ivermectin is a well-known anthelmintic, a positive allosteric modulator of glutamate-gated chloride channels. Some anthelmintics appear to have anti-malarial, anti-viral, and anti-cancer effects.

On the other hand, Molnupavir is a close cousin of Remdesivir. However Remdesivir cannot be taken orally. This was the goal of of the development of Molnupavir. This Nature article does a very good job of describing the pharmacokinetics/pharmacodynamics of Molnupavir:

"Similar to other nucleoside analogs, molnupiravir targets the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), which mediates replication and transcription of the coronavirus genome. Viral RdRps are proven effective targets for inhibition, with several licensed nucleoside analogs that are used therapeutically. Indeed, the only currently clinically approved antiviral used for the treatment of COVID-19 is remdesivir (Veklury), which targets the RdRp. Similar to remdesivir, molnupiravir has been re-investigated as a coronavirus antiviral agent that leads to increased frequency of G-to-A and C-to-U transition mutations."

22 posted on 10/13/2021 8:37:20 AM PDT by StAnDeliver (Each of you have at least ONE of these in your 401k: Pfizer, Moderna, AstraZeneca, Johnson & Johnson)
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To: StAnDeliver

Some highlights from the video and referenced comparison article

https://youtu.be/hKa3EZqofNo

https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf

Tmax (the time it takes to get to maximum plasma concentrations)
Molnupiravir : 1-1.75 hours
Ivermectin : 4-6 hours

Half life
Molnupiravir : 7 hours
Ivermectin : 81-91 hours (less than this according to some other researches, but still far better than Molnupiravir. Besides Ivermectin has the ability to accumulate in the lungs, which is very important for treating Sars-Cov-2 infection)

Inhibation of cytokine production and inflammation
Molnupiravir : Not known yet
Ivermectin : Effective

Total Cost/Price per treatment
Molnupiravir : 700 USD
Ivermectin : 0.53 USD

Safety/Adverse events
Molnupiravir : Unknown yet
Ivermectin : Very low number of adverse events (3.7 billion doses have been given to humans so far and only 5693 AE records retrieved. For comparison the number for ibuprofen is 165.479

More in the video above


26 posted on 10/13/2021 8:53:08 AM PDT by silverleaf (“Freedom ultimately means the right of other people to do things that you disagree with”. T. Sowell )
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