I've got Twitter, Facebook, and most Google services blocked. As a result, I don't get to some sites--including a couple of "conservative" sites--because they block the whole site when they detect my blocking.
I have found that if I do turn on the top Script listed “Domain.com” it meets the requirement needed to load the site. But then it adds several more scripts to the list NoScript is blocking. So even though I allowed the site JS so that things render correctly, NoScript is still catching and blocking the extra hidden stuff they try to shove on me when I toggle on the JS.
Once in awhile I might have to turn on the domain CDN too. The problem with some websites even if honest and innocent is that the website also incorporates JS for functions and graphics such as radio button links and Icons. So I think you can safely toggle on the top domain listing because NoScript is still blocking everything else.
Cool thing is, it will get around paywalls most times with just this top listing toggled on. :)
An example of this is our site. Hit it with NoScript. It is written in 99% PHP, so there is very little JS incorporated. You can see that the only thing not rendering correctly are the button icons, and the minimum needed in site “user experience” cookies to remember what you did for “your posts/viewed posts” Etc... For some reason button icons must be a challenge for PHP, but they still function.
But you can safely toggle on the one domain listing. We have absolutely NO hidden 3rd party scripts local from the site. Unfortunately though, when things are embedded such as videos “their” scripts are then added. I would personally like to outlink everything like here but folks like embedded stuff.