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"It was the world’s first endectocide, forerunner of a completely new class of antiparasitic agents, potently active against a wide range of internal and external nematodes and arthropods."
"The growing body of evidence supports the theory that the rapid microfilarial clearance following ivermectin treatment results not from the direct impact of the drug but via suppression of the ability of the parasite to secrete proteins that enable it to evade the host’s natural immune defence mechanism."
"Despite decades of searching around the world, the Japanese microorganism remains the only source of avermectin ever found.1) Originating from a single Japanese soil sample and the outcome of the innovative, international collaborative research partnership to find new antiparasitics, the extremely safe and more effective avermectin derivative, ivermectin, was initially introduced as a commercial product for Animal Health in 1981. It is effective against a wide range of parasites, including gastrointestinal roundworms, lungworms, mites, lice and hornflies."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/
J Antibiot (Tokyo). 2021 Jun 15 : 1–13. doi: 10.1038/s41429-021-00430-5 [Epub ahead of print] PMCID: PMC8203399 PMID: 34127807 The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article Asiya Kamber Zaidicorresponding author1,2 and Puya Dehgani-Mobaraki3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203399/
Looks like it interferes with the virus activity in a number of ways.
