“Read a paper that mentioned the possibility: certain diabetics meds that down-regulate ACE1 may cause increase in ACE2 expression. Increased ACE2 expression is fertile ground for SARS.”
I could certainly believe that. From the beginning, I’ve always wondered how the virus manages to know if someone has high blood pressure, as it’s unlikely that virus particles carry sphygmomanometers to measure blood pressure - so I figured it must be something else, and meds of course came to mind first.
I thought it’s simply stored iron.
Older people are at higher risk. They have more stored iron.
Men are at higher risk. They have more stored iron.
Excess iron causes diabetes. Excess iron can cause high blood pressure.
And if true, think about the Pharma conflict and lack of disclosure.
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7785422/
“Patients with hypertension are commonly treated with the renin angiotensin system (RAS) antagonists, such as angiotensin converting enzyme inhibitors (ACE1s) or angiotensin receptor blockers (ARBs) in the control of blood pressure.
“However, these drugs have been reported to increase the expression of angiotensin converting enzyme 2 (ACE2), which is recognized as the receptor of SARS-CoV-2 in the cell surface, especially the lung epithelial cells.
“Thus, there has been a speculation that this class of antihypertension drugs might facilitate the infection and replication of the virus.
“On the other hand, some researchers believed that the expression may be a beneficial response in terms of limiting the lung injuries by the infection. Collectively, the exact impact of ACE1s and ARBs in the infection is still under debate. Here we present two lines of justifications supporting the hypothesis that those hypertension medicines may reduce the mortality in COVID-19 patients.”
From the beginning, I’ve always wondered how the virus manages to know if someone has high blood pressure
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Meds may be implicated, but metabolic syndrome is likely the culprit in most cases of COVID that are serious .... obesity is a major comorbidity, diabetes, high blood pressure .... all symptoms of metabolic syndrome. Also, though not mentioned below, those with metabolic syndrome have a lot of inflammation .... already ‘inflamed’ and then along comes the inflammation of the cytokine storm & you’re screwed.
https://www.mayoclinic.org/diseases-conditions/metabolic-syndrome/symptoms-causes/syc-20351916
From link:
Metabolic syndrome is a cluster of conditions that occur together, increasing your risk of heart disease, stroke and type 2 diabetes. These conditions include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.
Having just one of these conditions doesn’t mean you have metabolic syndrome. But it does mean you have a greater risk of serious disease. And if you develop more of these conditions, your risk of complications, such as type 2 diabetes and heart disease, rises even higher.
Metabolic syndrome is increasingly common, and up to one-third of U.S. adults have it. [My note: this is the root cause of the so-called ‘obesity’ epidemic]