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Diabetics and those with atherosclerosis have too little SETDB2, which belongs to the KMT1 family of lysine methyltransferases. Your body needs lysine from protein and methyl donor groups, usually from B vitamins, but much more is available from betaine powder (comes from beets).

Methyl groups help other key processes in the body and we probably don’t get enough of it.

1 posted on 09/08/2021 7:04:29 PM PDT by ConservativeMind
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To: ConservativeMind

Interesting.

Diabetic type 2 old fart, and my covid bout was minor, which surprised my PA.

I’ll keep visiting this thread to keep up with the research and the article.

Thank you for posting.


2 posted on 09/08/2021 7:08:01 PM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: ConservativeMind
Deficiency of histone lysine methyltransferase SETDB2 in hematopoietic cells promotes vascular inflammation and accelerates atherosclerosis
https://insight.jci.org/articles/view/147984

Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice
https://pubmed.ncbi.nlm.nih.gov/19255798/

Are You Eating Methyl Donor Foods?
https://naturallysavvy.com/eat/are-you-eating-methyl-donor-foods/

Foods High in Lysine
https://www.webmd.com/diet/foods-high-in-lysine

3 posted on 09/08/2021 7:08:06 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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18 months to ask this question.

Read a paper that mentioned the possibility: certain diabetics meds that down-regulate ACE1 may cause increase in ACE2 expression.

Increased ACE2 expression is fertile ground for SARS.

Think about that.


4 posted on 09/08/2021 7:13:30 PM PDT by Gene Eric (Don't be a statist!)
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To: ConservativeMind

Bookmark


8 posted on 09/08/2021 7:29:53 PM PDT by RightField
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To: ConservativeMind

85 percent of diabetics are overweight.


9 posted on 09/08/2021 7:35:10 PM PDT by MMaschin (The difference between strategy and tactics!)
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To: ConservativeMind

Bkmk


11 posted on 09/08/2021 7:39:41 PM PDT by sauropod (Bidet was no prize before he put the “d” in “dementia.” - Schlichter)
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To: ConservativeMind

We have a son-in-law who’s pushing 50 who is a Type 1 diabetic on an insulin pump. He tested positive with Covid and was completely asymptomatic. Had his office not come down with it, resulting in everyone being tested, he wouldn’t even have known he had it.


13 posted on 09/08/2021 7:57:22 PM PDT by AlaskaErik (In time of peace, prepare for war.)
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To: ConservativeMind

I believe there is a large study that goes through most of the American data and it concludes that diabetes is not a predictor of bad outcomes when it comes to Covid. If you control for age and especially weight, you will see diabetes is not a factor. I think the three factors with the highest predictive correlation are Age, Weight and Vitamin D. Some think Vitamin D is also associated with the other two.


14 posted on 09/08/2021 8:03:00 PM PDT by poinq
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To: ConservativeMind

Simple answer is that high blood sugar weakens the immune system and makes it less able to fight off infections. Also, if you do get COVID-19, the infection could put you at greater risk for diabetes complications like diabetic ketoacidosis (DKA). DKA happens when high levels of acids called ketones build up in your blood. It can be very serious.

If you do get sick, check your blood sugar more often than usual. COVID-19 can reduce your appetite and cause you to eat less, which could affect your levels. You also need more fluids than usual when you’re sick. Keep water close by, and drink it often. And most of the over the counter medicines can cause high or lower blood sugars and the only real partially safe pain killer and fever reducers is acetaminophen, tylenol, but large quantities of it can give you false glucometer readings. Kind of between a rock and a hard place with C19.

wy69


17 posted on 09/08/2021 8:19:51 PM PDT by whitney69
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To: ConservativeMind

I have type 2 diabetes. I had COVID. I am fine. My diabetes is under control and my a1c is 5.7. I am wondering if you have it under control through diet and weight loss, is this a factor?


18 posted on 09/08/2021 8:20:06 PM PDT by Whatever Works
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