RE: Neem Leaf also does this.
What on earth is that? Care to explain?
RE: Neem Leaf also does this.
What on earth is that? Care to explain?
Neem Leaf is sold many places as a supplement. Like, Nature’s Way Neem Leaf for $4.61 for a 100 capsules.
Below are only a few of many studies showing Neem Leaf is a powerful anti-viral. Drug companies stay away as it cannot be patented, thus they cannot make mega dollars on it. In fact, it would take away profits they make on other drugs.
https://web.williams.edu/AnthSoc/native/neem.htm
INDIA WINS NEEM PATENT CASE
https://www.researchsquare.com/article/rs-25649/v1
Some Compounds from Neem leaves extract exhibit binding affinity as high as -14.3 kcal/mol against COVID-19 Main Protease (Mpro): A Molecular Docking Study
Conclusion
Naturally occurring Neem tree has a host of compounds on its leaves, bark, trunk, seeds. Neem leaves has been already known for its antiviral and antibacterial properties around the world. Since Meliacinanhydride and other compounds are derived from Neem leaves, ingesting Neem leaves extract powder or crude Neem leaves contains might inhibit the COVID- 19 virus by prevent it from replicating. Also Neem leaves are known to reduce blood sugar levels and also they act as ACE inhibitors. (Rotimi O. Arise, 2019) In addition to that Neem leaves has more than 140+ compounds like quercetin, zinc along with Vitamins like Vitamin C, E & K and ingesting them orally will also boost immunity. However, further in vitro and later in vivo tests are needed to evaluate compounds from Neem leaves as clinical drugs. Since the oral availability of these compounds are high further tests are needed to evaluate them against COVID-19 for clinical use.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532348/
Screening of potential drug from Azadirachta Indica (Neem) extracts for SARS-CoV-2: An insight from molecular docking and MD-simulation studies
4. Conclusion
The inhibitory effect of several molecules extracted from Neem (A. Indica) on PLpro protein of the SARS-CoV-2 (COVID-19) has been studied in the present work. All the 19 molecules studied showed potential docking ability with PLpro, along with toxicity and other values, while being nontoxic themselves, in comparison with 7 drugs currently being tested against COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311162/
A computational prediction of SARS-CoV-2 structural protein inhibitors from Azadirachta indica (Neem)
In conclusion, we have identified a few possible inhibitors of the E and M proteins of SARS-CoV-2 using molecular docking, MD simulation and binding free energy calculations. These compounds, derived from Neem, displayed stable binding and interactions with crucial regions of E and M required for assembly; and were predicted to have good pharmacokinetic properties. Nimbolin A showed the strongest binding free energy with both E and M proteins. Other compounds: Nimocin and Cycloartanols (24-Methylenecycloartanol and 24-Methylenecycloartan-3-one) were also common ligands, binding strongly to both proteins. A recent study has shown ameliorating effect of Neem extract on propagation and pathophysiology of another member of the coronavirus family (Sarkar et al., 2020), reinforcing the potential of these compounds as potential therapeutic options. Experimental validation and optimization of these natural compounds might add value to the development of specific therapeutics against SARS-CoV-2.