Ophiuchus means "serpent holder" (ophis = "serpent" in Greek). The snake in Acts 28.3 is described by a different term, echidna, "viper" (maybe to emphasize that it was a poisonous snake). The snake being held by the serpent holder is known by its Latin name (Serpens Caput and Serpens Cauda).
We now return you to your regularly scheduled herpetologist.
And it should be Recurrent Nova RS Ophiuchi, not Nova Ophiuchi.
Thanks for the lesson. I gotta brush up on my constellation lore. My astronomy club is starting up public viewing again. Finally!
I have been just writing RS Oph. The folks I was posting to knew what I meant. :D