“A major trigger for ADE is viral mutation. Changes to the amino acid sequence of the Spike Protein (which is the protein on the virus that facilitates entry into our cells via the ACE2 receptor) can cause antigenic drift.
What this means is that an antibody that was once neutralizing can become a non-neutralizing antibody because the antigen has slightly changed.
Therefore, mutations in the Spike protein that naturally occur with coronaviruses could presumably result in ADE. Since these future strains are not predictable, it is impossible to predict if ADE will become a problem at a future date.”
Could this be why my response to the J&J vaccine was severe as I already had Covid-19 a year earlier?