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To: ifinnegan

To add another layer of correction. Sars 1 infected don’t have antibodies 17 years later/ They have memory T-Cells with record of the virus.

That provides a more uncertain level of protection. By analogy antibodies are cops on the street actively hunting for a perp. Memory T-Cells is a wanted poster on a billboard at the police station.

The most likely scenario is that T-Cells prevent the infection getting severe. You might still get infected again, but it won’t become more than a mild cold.


21 posted on 07/26/2021 10:37:00 AM PDT by Renfrew
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To: Renfrew
"The most likely scenario is that T-Cells prevent the infection getting severe. You might still get infected again, but it won’t become more than a mild cold."

It really just depends. The cross-reactivity shown in the lab was outside the body and may not accurately represent a significant response in natural situations. Lab experiments are helpful tools, but more work would be needed to establish what the actual effect would be in the real world.

Macrophages and neutrophils would already be fighting SARS-CoV-2 virions in any healthy person. If some T cells join the fight, that's going to be helpful. The question the remains is: to what extent? Perhaps it's enough to completely halt infections in their tracks. Unlikely, given the lack of significant numbers of T cells and the lack of coordinated B cell lymphocyte action, but who knows. Maybe it reduces the severity of infection as you suggested. That's certainly possible. It may also be that actual cross-reactivity in the body is minimal and the T cells aren't even that involved.

The difficulty here is that challenge trials are unethical and the pool of SARS2003 survivors is so tiny that you'd have a hard time studying this any other way. It's interesting data, and with luck we'll see some useful long-lasting immune system reaction with COVID-19. So far, those who were previously infected with SARS-CoV-2 appear to have great immunity moving forward. That's great news.

24 posted on 07/26/2021 11:01:20 AM PDT by 2aProtectsTheRest (The media is banging the fear drum enough. Don't help them do it.)
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To: Renfrew

“... don’t have antibodies 17 years later/ They have memory T-Cells with record of the virus.”

Antibodies are expressed on the surface of the memory cells. They proliferate when encountering the antigen.

Soluble antibodies probably are present but too low to detect.


30 posted on 07/26/2021 11:53:38 AM PDT by ifinnegan ( Democrats kill babies and harvest their organs to sell)
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