[[VParkin’s job is to clear away mitochondria that have been damaged by cellular stress so that new ones can take their place, a process called mitophagy. However, Parkin is mutated in familial Parkinson’s disease, making the protein unable to clear away damaged mitochondria. ]]
I’ll try again, the last reposnses I thjnk wer e nt the greatest
Think of the body running an a bunch of batteries that the boy constantly replenishes when they die or get weak. The Larkin somehow sense that the batteries have died, and come in and clear them so the body can replace them with new strong ones, enabling the body to keep on functioning at a high level to fight off diseases and such.
In Parkinson’s disease, the parkin can no longer clear put the old dead or dying batteries that are ‘stressed, so the body can’t put new strong healthy batteries in their place anmore, so the body gets weaker and weaker as more and more dead batteries accumulate. The body no longer has ‘full power to fight off diseases and whatnot
Something tips off the parkin that the batteries are dying. Researchers have zeroed in on what they think tips them off
Possibly metformin, a diabetes drug, may trigger something that initiates the parkin. To go in and clear, out the dead batteries so that new ones can be placed.
This ‘may mean’ longer life, less aging related diseases because the body has more energy because the mitochondria, the bodies powerhouse cells,, are healthy and more numerous now again, which enables them to energize the body so it can fight off diseases and such now.
There are a,ways problems iwth analogies, but I think this kinda sums up what is going on
Dang it. Autocorrect strikes Agatha ‘body’ constantly replaces,
And the ‘parkin’ somehow sense that the batteries have died, or rather that the mitochondria are damaged