SAMe, plus a B-12/folic acid patch, work wonders for me.
A B-12/folic acid patch sounds fine, and Lions’s Mane sounds interesting, but I am wary about taking SAMe because the body can turn it into toxic homocysteine. TMG converts homocysteine into SAMe, and I think that is safer than taking SAMe directly.
People for whom TMG or SAMe doesn’t help their depression might want to try 5HTP(5-hydroxy-tryptophan), which is a serotonin precursor, and a natural alternative to Prozac. https://pubmed.ncbi.nlm.nih.gov/11687048/