The animals all experienced autoimmune responses - their immune systems attacking their own organs - after being immunized and then later exposed to live SARS viruses post-immunization:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421
Note, this autoimmune response wasn’t limited to the RNA-based vaccine, but happened with all the mice, even the ones give the other 3 types of vaccines:
“challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.”
Thank you, that is extremely interesting, the data is appreciated.