A crewed aircraft or space mission is dependent on a fairly significant amount of weight and equipment needed to maintain survivability and recovery of a crew.
I would like to see more robotics deployed. Most bang for the buck.
Humans can rehearse bio needs on the moon. Robotics to mine the abundant H³ found there and techs to keep the robitics in good working condition. Housing will eventually go to the volcanic lava tubes, properly fitted out, as sans atmosphere the radiation can’t really be controlled any other way.
Life kinda sucks out there in the wilds of the heliosphere.
Lots of good points there.
I’ll add that an alcohol-based economy- providing food for humans and animals and fuel for export is more likely than a an H3 economy.