To create INOVIO’s Pan-COVID-19 vaccine candidate, variant sequences were identified over a four-month period starting in October 2020 from multiple geographic regions (Brazil, Canada, India, Italy, Japan, Nigeria, South Africa, United Kingdom, and the United States). Mutations in the spike sequences were aggregated for each region.
The sequence results from these regions were then further engineered to determine a common set of overlapping mutations from emerging variations in the COVID spike protein sequences to generate INO-4802.
Yup. That’s all I want. A synthetic DNA vaccine.
I am not a virologist but I would guess that there are many antigenic sites on coronavirus variants. Why tinker with dna, rna...when one can kill or attenuate the viruses, break them down, extract and dispose their dna or rna...and give the remaining parts as a vaccine to stimulate an antibody response?