The author of the study also replied to a question about Novavax which I was wondering about because that vaccine skips mRNA or adevovirus vector completely and injects spike protein instead. Here’s what he had to say about that:
Joseph
commented on 27 May, 2021
The Novavax vaccine is a protien subunit vaccine. It does not go through transcription or translation but would it have a similar affect to blood clotting?
REPLY
Report
View 1 reply
icon
Rolf Marschalek
replied on 27 May, 2021
I dont think so....think about the timing. If you vaccinate a person with such a vaccine, it will be taken up by professional phagocytosing cells that then trigger the immune response, but when first antibodies become available, the antigen is mostly gone - apart from the few B cells that still bind it with the membrane IgM. This is different to mRNA vaccine, where you mostly have surface expression for the time the mRNA is still present, and gain different to vector based vaccines that are longer stable in the cells and produce still antigen when the immune system already started to produce first antibodies against the antigen.
The Noravax vaccine holds great promise IMO. It would seem to address much of the concern some have with the current vaccines and I understand it to be much easier to store making it readily available to poorer counties too.
Have you seen any reason given for the several months’ delay in them seeking EUA?